An agent such as an Act-A antigen fusion protein has the ability to generate a therapeutic anti-tumor immune response; even in the presence of pre-existing immune tolerance. John Rothman, Executive Vice President of Technology and Operations.. Advaxis’ Listeria based fusion protein granted U.S. Patent The US Patent and Trademark Workplace has released Advaxis, Inc. Advaxis provides patents on two groups of antigen-fusion proteins based upon the Listeria proteins Act-A and LLO. Act-A is known to have nonspecific immune stimulating adjuvant properties. Immune tolerance happens when repeated immunogenic stimulation outcomes in fatigue of the immune system and an inability to mount a therapeutic response.Early-age drinkers are at a larger risk of developing a cancer. This is because the alcohol-related carcinogens have a larger impact on our body during tissue-growth or development phases. Regarding breast cancer, early-age woman drinkers are at a larger risk during mammary development. Nevertheless, pre – and post-menopausal position in women did not show noticeable variations toward cancer risk. Folic acid/Folate/Supplement B9: Folate is usually a supplement required for normal DNA synthesis in the body. A review on nutrition was done by the Globe Cancer Research Fund, and it was found that supplement B, or folate, could be a preventive factor for breast cancers caused because of alcohol consumption. The actual fact also remains that all heavy drinkers have been reported to be deficient in folate because of either reduced absorption or increased excretion.