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Study co-authors include Paul Darden, M.D., David Thompson, Ph.D., Jessica Hale, and Monique Naifeh, M.D., M.P.H., University of Oklahoma; and James Roberts, M.D., M.P.H., and Charlene Pope, Medical University of South Carolina. The study was supported by grant R40 MC 21522 through the U.S. Department of Health and Human Services' Maternal and Child Health Research Plan. Dr. Darden offers consulted and advised Pfizer Inc. Dr Jacobson has offered as principal investigator for just two multicenter vaccine research funded by Pfizer, one funded by Novartis, all at Mayo Clinic.‘Patients suffering from this degenerative osteo-arthritis either move through a total joint replacement, or are pressured to live with discomfort every day. This discovery, however, supports that adding a lubricin replacement to the fluid in joints may in fact prevent osteoarthritis in those who have a genetic predisposition to the illness, or who have suffered significant trauma to the joints.’ Jay added, ‘We are working to create a replacement for natural lubricin that people hope will significantly improve the treatment options, and prevention measures ultimately, for those with early osteoarthritis, or people that have joint accidental injuries.’ OA, the most typical form of arthritis, is an agonizing joint disease that can place severe limitations on daily activity and standard of living.